Blood Vessel Differentiation Through Vascular Endothelial Growth Factor (IMAGE)
Caption
(A) This is an epigenetic landscape was observed in the EC generation stage. Methylation state on the histone tail on the chromatin, histone code, in endothelial cells was read via hi-speed deep sequencer. (B) Histone marking on the regulatory region of EC master transcription factors was switched following the order, (1) release the brake mark and then (2) enter the acceleration mark. (C) A new concept proposal for the EC differentiation switch. Dynamic epigenetic analysis revealed that differentiated ECs were tightly regulated via histone modification switch, which looks like a baton pass, rather than bivalent histone modifications. Adapted from: Y. Kanki, R. Nakaki, T. Shimamura, T. Matsunaga, K. Yamamizu, S. Katayama, J. Suehiro, T. Osawa, H. Aburatani, T. Kodama, et al., "Dynamically and epigenetically coordinated gata/ets/sox transcription factor expression is indispensable for endothelial cell differentiation.," Nucleic acids research, Mar. 2017. DOI: 10.1093/nar/gkx159
Credit
Professor Takashi Minami
Usage Restrictions
This image may only be used in conjunction with the accompanying release, or stories written about the work described in the release with reference to the original work.
License
Licensed content