Post-Zygotic Autism Mutations in the Prenatal Brain (IMAGE)
Caption
Lim, Walsh and colleagues overlapped the post-zygotic mutations they identified from blood DNA samples with publicly available gene expression data from brain autopsies (via the BrainSpan Project). This enabled them to roughly map the brain regions in which the mutated genes are expressed. In this image, representing prenatal brain samples, the biggest hit was the amygdala (AMY), in red. There were minor hits in the striatum (STR) and cerebellar cortex (CBC) that did not reach statistical significance.
Credit
Mohammed Uddin
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