Cryo-Em Shows It All (IMAGE) University of Pennsylvania School of Medicine Caption The Structure of BRISC in association with SHMT2. BRISC-SHMT2 complexes were solved using cryo-electron microscopy. The BRISC deubiquitylase complex is a U shaped dimer. Each side of this symmetrical complex is comprised of four subunits, including Abraxas2, BRCC36, BRCC45, and MERIT40. Two SHMT2 proteins form a dimer to bridge each side of the BRISC. The interactions within complex are required for innate immune signaling and represent an attractive drug target for diseases such as lupus that that are exacerbated by elevated inflammatory signals. Credit Miriam Walden, Leeds University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.