Cleft FGF Image (IMAGE) University of Iowa Caption University of Iowa researchers have discovered that mutations in FGF signaling pathway genes contribute to cleft lip and palate. The top figure shows the normal sequence for a region of the FGFR1 gene; the bottom figure shows a mutation in the same region for a person with cleft lip and palate. Credit University of Iowa, Jeff Murray Lab/Bridget Riley Usage Restrictions Must be used with credit line. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.