Chemical Structure of Metabolite (IMAGE)

NIH/National Institute of Mental Health

Chemical Structure of Metabolite

Caption

A team of NIH intramural scientists and grantees traced ketamine's rapid antidepressant effects to activation of AMPA receptors by a byproduct of its chemical breakdown called (2R,6R)-HNK - a different mechanism than had been previously assumed.

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NIH - National Center for Advancing Translational Sciences

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