Dormant Seeds of Metastasis (IMAGE)

Cold Spring Harbor Laboratory

Dormant Seeds of Metastasis

Caption

On the left is a section of a pancreatic cancer patient's primary tumor, with cancer cells (red) and CK19, a marker of proliferation (green), evident. On the right is a sample of the liver in the same patient revealed 27 isolated DCCs (disseminated cancer cells). These cells are dormant, but activate when T cell levels in the patient drop, as they do immediately following surgery. This provides a clue about how to avoid liver metastasis in pancreatic cancer patients who undergo surgery.

Credit

Fearon Lab, CSHL

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