In the Absence of Disabled-2 , Vps34/Beclin-1 Interactions are Maintained (IMAGE)

Medical University of South Carolina

In the Absence of Disabled-2 , Vps34/Beclin-1 Interactions are Maintained

Caption

Immunofluorescence analysis to detect the expression and localization of Vps34 and Beclin-1 in cathepsin B overexpressing mouse mammary epithelial (CTSB/OE cells) treated -/+ TGF-beta? for 7 days. Photos were taken by confocal microscope. Scale bars, 10 m. The data show that in the absence of Dab2, due to CTSB overexpression, Vsp34/Beclin-1 interactions are maintained and autophagy is initiated.

Credit

Adapted from a figure originally published online ahead of print on July 11, 2016 in Nature Cell Biology (doi: 10.1038/ncb3388) in an article by Jiang Y, Woosley AN, Sivalingam N. Natarajan S, and Howe PH.

Usage Restrictions

Please release image only to registered reporters until the embargo passes. Please use credit line as provided.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.