TsrM crystal structure and reaction (IMAGE)
Caption
The synthesis of the potent antibiotic thiostrepton uses a radical SAM protein TsrM, whose crystal structure is shown at left while bound to an iron-sulfur cluster and cobalamin. New images of this crystal structure allowed researchers from Penn State to infer the chemical steps during the antibiotic's synthesis (right), as a methyl group moves from a molecule called S-adenosyl-L-methionine (SAM) to the cobalamin in TsrM to the substrate tryptophan.
Credit
Booker Lab, Penn State
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