Figure 2: The Mechanism for Production of High-Quality Pluripotent Epiblast Cells (IMAGE)

The University of Osaka

Figure 2: The Mechanism for Production of High-Quality Pluripotent Epiblast Cells

Caption

Activation of the TEAD transcription factor in the inner cell mass induces strong expression of pluripotency factors, which is required for epiblast formation. The expression of pluripotency factors (i.e., the quality of pluripotency) is highly variable among epiblast cells. Thus, the quality-control mechanism, which eliminates low-quality cells via apoptosis, operates to produce a high-quality epiblast.

Credit

Osaka University

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.