In vivo delivery of Cre-recombinase (gene editing protein) into the mouse brain (IMAGE)

Tufts University

In vivo delivery of Cre-recombinase (gene editing protein) into the mouse brain

Caption

A successful transfer of Cre-recombinase packaged in an NT-lipidoid-doped lipid nanoparticle is demonstated when the Cre-recombinase activates expression of the tdTomato fluorescent protein in the cells of the mutant mice. Transfected neurons located throughout the brain (cerebellum shown here) light up in red (scale bar 100μm) Inset: TEM image of lipid nanoparticles containing Cre-recombinase (scale bar 0.1μm).

Credit

Qiaobing Xu, Tufts University

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