T-cell co-stimulation pathways (IMAGE)

Medical University of South Carolina

T-cell co-stimulation pathways

Caption

This figure depicts the two major T-cell co-stimulation pathways, ICOS and CD28, targeted by the new drug candidate ALPN-101 as compared to CTLA-4-Fc CD28/B7 pathway inhibitors (abatacept and belatacept) for the treatment of graft-versus-host disease.

Credit

Alpine Immune Sciences

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