<I>Streptococcus pyogenes</I> Toxin and Antitoxin (IMAGE)
Caption
The Streptococcus pyogenes toxin SPN (shown in purple) is inhibited by the antitoxin IFS (left, shown in orange). IFS blocks the active site of SPN and prevents NAD+ from binding. When bound to SPN, one end of IFS is folded into a compact form (upper right, shown in green). Alone, the same end of IFS extends straight out (lower right, shown in green). Forcing IFS to stay in this free state would release the SPN toxin to attack the bacteria themselves.
Credit
Image provided by Craig L. Smith
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