Areas of the Brain (IMAGE) Columbia University Irving Medical Center Caption The brain area outlined in yellow is the hippocampus; the dentate gyrus is shown in green and the entorhinal cortex in purple. Previous work, including by the laboratory of senior author Scott A. Small, M.D., had shown that changes in a specific part of the brain's hippocampus -- the dentate gyrus -- are associated with normal age-related memory decline in humans and other mammals. The dentate gyrus is distinct from the entorhinal cortex, the hippocampal region affected in early-stage Alzheimer's disease. Credit Lab of Scott A. Small, M.D. Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.