Image1: Strong Chewing Modulates Igf-1 Expression in Osteocytes for the Jawbone Reconstruction (IMAGE)
Caption
a. Superimposition of the jawbone images acquired by the computer simulation. Blue: before remodeling and red: after remodeling. Left: coronal section and right: lateral projection. The dotted circle indicates the extrusion of the bone. The blue and the red lines denote the mandibular height. <p>b. Distribution of the mechanical stress in the jawbone, before and after remodeling under the increased mastication. <p>c. Superimposition of the images of the jawbone of mice fed with the HD or ND. Blue: ND and red: HD. The dotted circle indicates the extrusion of the bone. The blue and the red lines denote the mandibular height. <p>d. Immunohistological images of the jawbone of mice fed with the HD or ND. IGF-1 (red); and nuclei (blue). The dotted lines indicate the jawbone surface. Arrows indicates the osteocytes expressing IGF-1. <p>e. Graphical abstract. In order to consume harder foods, masticatory muscles generate stronger force that induces mechanical stress in the jawbone. The stress stimulates osteocytes to produce IGF-1. The upregulated IGF-1 enhances osteoblastogenesis to reconstruct the jawbone morphology so that it endures the loaded force.
Credit
Department of Cell Signaling,TMDU
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