Thioketal Nanoparticles (IMAGE)

Georgia Institute of Technology

Thioketal Nanoparticles

Caption

When delivered orally, thioketal nanoparticles remain stable in the harsh environment of the gastrointestinal tract, protecting siRNA and preventing its release to non-inflamed tissues (top). However, at sites of intestinal inflammation where unusually high levels of reactive oxygen species are present, the thioketal nanoparticles degrade and release siRNA to the site of inflammation (bottom).

Credit

Scott Wilson

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