Chandelier Cell Fibers (IMAGE)
Caption
The long, reaching fibers -- called cartridges -- of a single chandelier cell (ChC) can be seen highlighted in red in this image. Each fiber forms a lasting connection with a neighboring pyramidal neuron (PyN) (green). This partnership ensures the PyNs don't become overexcited, a state which can result in problems like epilepsy and even neuron death. The anchor protein AnkG (blue) helps hold an essential molecule (see inline image) to the axon initial segment of the PyN, which in turn maintains the crucial connection with the ChC cartridge.
Credit
CSHL/Van Aelst
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