<sup>225</sup>Ac Alpha Therapy (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

<sup>225</sup>Ac Alpha Therapy

Caption

225Ac-proteus-DOTA hapten can be targeted in vivo to GPA33-expressing human colorectal cancer xenografts using anti-GPA33-DOTA-PRIT, with minimal radioactive uptake in critical radiosensitive tissues such as blood and kidney. In addition, indium-111 can be used in place of 225Ac as a convenient imaging surrogate (biomarker) of 225Ac in vivo biodistribution and dosimetry.

Credit

SM Cheal et al., Memorial Sloan Kettering Cancer Center, New York, NY.

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