Imaging a Blood Clot (IMAGE)
Caption
A blood vessel (top) with ruptured atherosclerotic plaque, shown in yellow, is developing a blood clot. The nanoparticles, shown in blue and black, are targeted to a protein in the blood clot called fibrin, shown in light blue. A traditional CT image, bottom left, shows no difference between the blood clot and the calcium in the plaque, making it unclear whether this image shows a clot that should be treated. A spectral CT image, bottom right, "sees" the bismuth nanoparticles targeted to fibrin in green, differentiating it from calcium, still shown in white, in the plaque.
Credit
Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission.
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