Pathological Hallmarks of AD (IMAGE) Public Relations Pacific LLC Caption Shown here are the pathological hallmarks of Alzheimer's disease, beta-amyloid plaques (brown spots), as seen both in brain and retinal tissues from deceased patients, as described in the Aug. 17 edition of Journal of Clinical Investigation Insight (Koronyo et al. 2017). The structures of these plaques in the brain and retina are very similar (classical and vascular-associated deposits; bv = blood vessel), suggesting that the retina faithfully represent the brain disease. Credit Image adapted from <i>JCI Insight</i>. 2017; 2(16):e93621. doi:10.1172/jci.insight.93621 Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease Yosef Koronyo ... Keith L. Black, Maya Koronyo-Hamaoui Published Aug. 17, 2017 Citation Information: <i>JCI Insight</i>. 2017;2(16):e93621. doi:10.1172/jci.insight.93621 Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.