Pathological Hallmarks of AD (IMAGE) Public Relations Pacific LLC Caption Shown here are the pathological hallmarks of Alzheimer's disease, beta-amyloid plaques (brown spots), as seen both in brain and retinal tissues from deceased patients, as described in the Aug. 17 edition of <i>Journal of Clinical Investigation Insight</i> (Koronyo et al. 2017). The structures of these plaques in the brain and retina are very similar (classical and vascular-associated deposits; bv = blood vessel), suggesting that the retina faithfully represent the brain disease. Credit Image adapted from <i>JCI Insight</i>. 2017; 2(16):e93621. doi:10.1172/jci.insight.93621 Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease Yosef Koronyo ... Keith L. Black, Maya Koronyo-Hamaoui Published Aug. 17, 2017 Citation Information: <i>JCI Insight</i>. 2017;2(16):e93621. doi:10.1172/jci.insight.93621 Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.