Buildup of Abnormal Antibodies (IMAGE)

St. Jude Children's Research Hospital

Buildup of Abnormal Antibodies

Caption

St. Jude Children's Research Hospital scientists have discovered that the tumor suppressor protein PTEN also ensures that regulatory T cells function properly and helps maintain a balanced immune response. Deleting PTEN from the regulatory T cells of mice was associated with immune abnormalities and kidney damage is a hallmark of lupus. The image on the left shows the buildup of abnormal antibodies (in pink) in the kidney of mice, following deletion of PTEN from regulatory T cells. Original image: Cliff Guy, Ph.D.

Credit

Cliff Guy, Ph.D., St. Jude Children's Research Hospital

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.