SIRT3 Effects (IMAGE) University of Chicago Medical Center Caption Honokiol, by increasing SIRT3 levels, effectively blocked both the induction and progression of cardiac hypertrophy in mice. Credit Mahesh Gupta, Ph.D., director of the Cardiac Cell Biology Research Program at the University of Chicago Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.