Mice and liver (IMAGE) Johns Hopkins Medicine Caption After being placed on high-fat diets, mice were either selected to take the PDE9 inhibiting oral drug or a placebo. The PDE9 inhibitor reduced total body and liver fat in mice without altering diet or physical activity. However, mice taking the placebo continued to gain body and liver fat throughout the 6-8-week drug trial. Credit Images courtesy of David Kass Usage Restrictions None License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.