Faster, Cheaper Test Can Help Predict Risk of Metastasis in Prostate Cancer Patients (IMAGE)

Elsevier

Faster, Cheaper Test Can Help Predict Risk of Metastasis in Prostate Cancer Patients

Caption

Schematic of copy number alteration (CNA) target probe set and anchor probe set placement. Shown (y-axis) are normalized (standard normal distribution) CNA log-rank scores for several cohorts of prostate cancer research samples. Log-rank scores outside 2 standard deviations from the mean (here, above 2 or below -2) indicate statistically significant evidence of a copy number gain or loss, respectively. CNA target probe sets [red rectangles, not to scale, with left-hand side (LHS) and right-hand side (RHS)] are placed throughout the region known to exhibit CNAs (here, around CC2D1A gene). Anchor probe sets (green rectangles, not to scale, with LHS and RHS) are placed in regions previously identified as copy number invariant. The number of sequenced amplification products for CNA target probe sets, normalized by the number of sequenced amplification products for anchor probe sets, serves to estimate copy number (copy number gain in the example shown). MB, megabase.

Credit

<em>The Journal of Molecular Diagnostics</em>

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