Dendritic Cells (IMAGE)

The University of Osaka

Dendritic Cells

Caption

Dendritic cells (red) are attracted to high-endothelial venules (HEVs, green) in order to warrant function and integrity of these blood vessels in lymph nodes (left). When HEVs are impaired in activation of sphingosine-1-phosphate receptor-1 signaling (right), dendritic cells fail to interact with HEVs resulting in suppression of white blood cell trafficking into lymph nodes and suppressed immune responses.

Credit

Image by Dr. Szandor Simmons, Osaka University

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