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Princess Máxima Center for Pediatric Oncology

Graphic Abstract

Caption

Osorio et al. report lifelong mutation accumulation in human hematopoietic stem and progenitor cells, which is explained by three distinct mutational signatures. Shared somatic mutations between cells of the same donor enable the construction of a developmental lineage tree and quantification of each branch to mature blood cell populations.

Credit

Osorio et al., <em>Cell Reports</em>, 2018

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