Elucidation of regulatory mechanism of Ulk1 in alternative autophagy. (IMAGE)

Tokyo Medical and Dental University

Elucidation of regulatory mechanism of Ulk1 in alternative autophagy.

Caption

Genotoxic stress induces Ulk1 dephosphorylation at Ser637 in a p53/PPM1D-dependent manner. The dephosphorylated Ulk1 is then phosphorylated at Ser746 by a necroptosis initiator, RIPK3, and translocates to the Golgi, which results in alternative autophagy (left). TNF signaling induces necroptosis but not alternative autophagy (right).

Credit

Department of Pathological Cell Biology, Medical Research Institute,TMDU

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