3-D Structure of Influenza B Virus Protein Binding Human ISG15 Infection-fighting Protein (IMAGE)

Rutgers University

3-D Structure of Influenza B Virus Protein Binding Human ISG15 Infection-fighting Protein

Caption

Three-dimensional structure of a complex between influenza B virus protein, NS1B, is represented as the solid form, and the human protein that fights infections, ISG15, is represented as pink and magenta ribbons and strands. The sequence of the ISG15 protein found only in humans and non-human primates, represented as a short dark blue strand, binds to the NS1B protein, immobilizing ISG15 and preventing it from fighting the virus. Researchers determined the structure using X-ray crystallography.

Credit

Rongjin Guan, et. al., Rutgers and University of Texas at Austin

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