Small RNAs Behind Cell Death from Fat and Sugar Overload (IMAGE)
Caption
Under normal conditions (left), the small nucleolar RNAs involved with cell death are not activated and are not visible around the nuclei of these mouse muscle cells (shown in green). In the presence of fats, however (right), the RNA molecules (shown in red) are activated and move out of the cell nuclei and into the cytoplasm, the liquid in the main body of the cell, where they help initiate cell death. This is the first time these small RNAs have been shown to function in the cytoplasm.
Credit
Jean E. Schaffer, M.D.
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