Chronotherapy Treadmill (IMAGE)

University of Pennsylvania School of Medicine

Chronotherapy Treadmill

Caption

The image depicts transcription factors SREBP and PPAR-alpha, which develop circadian rhythms that control the newly oscillating fat metabolism. SREBP, the rear wheel, directly drives fat synthesis and indirectly drives synchronous changes in fat burning via the front wheel, PPAR-alpha. The water bottle contains an agonist ligand for PPAR-alpha, which adds driving force to PPAR-alpha.

Credit

Annie Spikes, Dongyin Guan and Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania; <i>Cell</i>

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