Brain Reward Circuit (IMAGE)

NIH/National Institute of Mental Health

Brain Reward Circuit

Caption

The transcription factor deltaFosB mediates resilience in the nucleus accumbens, hub of the brain’s reward circuit. It is the target of an intensive high tech screening for small molecules that tweak it, which could lead to a new class of resilience-boosting antidepressants.

Credit

Eric Nestler, M.D., Mount Sinai School of Medicine

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