Human Pancreas Tumor Organoids (IMAGE)

Cold Spring Harbor Laboratory

Human Pancreas Tumor Organoids

Caption

Researchers discovered that pancreas cancer subtypes can switch between a slow-growing type and another more invasive and deadly form. This image shows human pancreas tumor "organoids" (five large circular structures). The organoids contain many cells that overexpress K-Ras (in red), a notorious driver of many cancers. Cells that express more K-ras behave more dangerously, dividing more frequently and invading surrounding tissues. Note the dense mats of blue stained cell nuclei, indicating that the cells are dividing quickly. Green stains F-actin, which shows the shapes of cells.

Credit

Miyabayashi/Tuveson lab, CSHL

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