Thermoregulation (IMAGE) Society for Neuroscience Caption Letrozole (20 μg/day, p.o.) exerts sex-specific reduction in thermoregulation during thermal challenge. (A) Facial temperature was measured via thermal camera during a 20-min thermal challenge. Representative images obtained 5 min and 20 min into the challenge are shown, along with the temperature reading. Percent change in temperature (°F) from the first min of the thermal challenge was plotted over time for females (B; Vehicle: n = 2; Letrozole: n = 4) and males (C; Vehicle: n = 5, Letrozole: n = 4). Letrozole treatment resulted in greater elevation in temperature across time for females only (p < .001). Error bars = SEM. Credit Gervais et al., JNeurosci (2018) Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.