GAPLINC graphic (IMAGE) University of California - Santa Cruz Caption GAPLINC, a highly conserved long noncoding RNA, modulates the immune response during endotoxic shock. Reducing or eliminating GAPLINC led to enhanced expression of inflammatory genes in both mouse and human cells. In a mouse model of sepsis, knockout mice without GAPLINC were protected from endotoxic shock. Credit Apple Vollmers Usage Restrictions For use only with news coverage of this research. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.