Model for Action of Baf60c (IMAGE)

Gladstone Institutes

Model for Action of Baf60c

Caption

This represents how the cardiogenic factors turn on heart genes. The transcription factors, Tbx5 and Gata4, can't access the DNA unless Baf60c is present. When all three are introduced, Baf60c helps open up the closed chromatin, and lets Tbx5 and Gata4 work together to turn on the heart genes.

Credit

Benoit Bruneau, The Gladstone Institute of Cardiovascular Disease

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.