The Origin Recognition Complex (IMAGE) Cold Spring Harbor Laboratory Caption The Origin Recognition Complex (ORC) is a group of proteins required to be fully assembled for the first step in DNA replication. One component of the ORC, ORC1 (visible in this image as bright green dots), is sequestered into droplets in the nucleus of the cell, and allowed to move briefly and assemble with other proteins at the right moment in the cell cycle. Credit Manzar Hossain/Stillman lab/CSHL, 2021 Usage Restrictions Attribution required License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.