Bortezomib's Neuropathic Effects Are Reversed by Fingolimod (IMAGE)

Rockefeller University Press

Bortezomib's Neuropathic Effects Are Reversed by Fingolimod

Caption

Compared with control animals (left), the spinal cords of rats treated with bortezomib (center) contain increased numbers of activated astrocytes (green) that cause neuropathic pain. Bortezomib's effects are prevented by the multiple sclerosis drug fingolimod (right), which inhibits the sphingolipid metabolite receptor S1PR1.

Credit

Stockstill et al., 2018

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