Genetic Risk (IMAGE)
Caption
People typically inherit two copies of genes, one from each parent, so some people have two different versions while others have two of the same version. Only one percent of the study participants were judged to be at high risk for developing suicidal thoughts while taking citalopram – due to having two copies of the high risk version of the GRIK2 gene, with or without any copies of the GRIA3 gene version. About 41 percent of study participants were considered at elevated risk since they had one or two copies of the GRIA3 version, but no copies of the GRIK2 version. Most (58 percent) participants were considered at lower genetic risk for treatment-emergent suicidal thinking, since they carried neither high risk gene version.
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NIMH Mood and Anxiety Disorders Program
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