3-D Atomic Structure of Myasthenia Gravis Interacting with Nicotinic Acetylcholine Receptors (IMAGE)

University of Southern California

3-D Atomic Structure of Myasthenia Gravis Interacting with Nicotinic Acetylcholine Receptors

Caption

To solve the structure of myasthenia gravis, scientists mixed proteins from the nAChR a1 and myasthenia gravis auto-antibody, to create crystals of the nicotinic acetylcholine receptors, a neuromuscular receptor responsible for movement, as it is disrupted by the autoimmune disease, myasthenia gravis. The crystals were shot with an X-ray (synchrotron, Advanced Photon Source in Chicago) to solve the structure.

Credit

USC Chen lab and Advanced Photon Source in Chicago

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