Simultaneous Deletion of Tetraspanins (IMAGE)

The University of Osaka

Simultaneous Deletion of Tetraspanins

Caption

Simultaneous deletion of tetraspanins CD9/CD81 in mice progressively exhibits a variety of accelerating aging phenotypes such as cataracts, osteoporosis, emphysema, skin atrophy, muscle atrophy, and shorter survival. Of note, its underlying mechanism would be downregulation of SIRT1, a key anti-aging molecule. Therefore, DKO mice could be a novel and unique model for both COPD and accelerated senescence.

Credit

Yoshito Takeda

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