Schematic model of the distinct types of stem cell divisions determine HF homeostasis and aging. (IMAGE)
Caption
Young HFSCs undergo symmetric cell divisions (SCDs) and asymmetric cell divisions (ACDs) to generate new bulge cells for their self-renewal and expansion. Whereas aged HFSCs provoke hemidesmosomal instability including COL17A1 and undergo stress response (SR) type ACDs to induce epidermal differentiation that triggers their delamination, thereby causing stepwise miniaturization of HFs and hair thinning and loss.
Credit
Department of Stem Cell Biology,TMDU
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