Non-B DNA mutation rate (IMAGE)
Caption
New research shows that DNA that folds into conformations other than the classic double helix (non-B DNA), which includes as much as 13% of the human genome, leads to elevated nucleotide substitution rates in both the non-B motifs themselves and their flanking regions. These elevated mutation rates are a major contributor to the regional variation in mutation rates across the genome.
Credit
Wilfried Guiblet and Dani Zemba, Penn State
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