Fig.1 Osteoblastic Bone Metastasis Induced by Cancer-secreted MicroRNAs (IMAGE)

_Tokyo Medical and Dental University

Fig.1 Osteoblastic Bone Metastasis Induced by Cancer-secreted MicroRNAs

Caption

In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of the osteoblastic or osteolytic phenotype. MicroRNAs are transferred between cells via exosomes and influence the phenotypes of their recipient cells. The present study demonstrated that cancer-secreted microRNAs induced osteoblastic bone metastasis through promoting the osteogenic differentiation of bone-forming cells.

Credit

Department of Physiology and Cell Biology,TMDU

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.