TIME Models for Growth of Oligonucleotide Technologies (IMAGE)

Bentley University

TIME Models for Growth of Oligonucleotide Technologies

Caption

(A) Annual publications in PubMed related to oligonucleotide therapeutics (markers) and best fit TIME model (lines). The TIME model uses the best fit exponentiated logistic function based on the cumulative number of publications (inset graph). Data indicated with open markers could not be fit to this function. (B) The logistic ("S curve") representation of the TIME model is shown on a log scale. Note that the apparent residuals are exaggerated at the low end of the log scale (see Materials and Methods). Dates of FDA approval of oligonucleotide therapeutics are indicated, including those for fomivirsen (1998, subsequently withdrawn from market), mipomersen (2013), nusinersen (2016), and eteplirsen (2016).

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Center for Integration of Science and Industry, Bentley University

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