How Dicer Protects the Yeast Genome from Damage (IMAGE)

Cold Spring Harbor Laboratory

How Dicer Protects the Yeast Genome from Damage

Caption

CSHL scientists have found a new role for the RNAi protein Dicer in preserving genomic stability in yeast. Dicer helps prevent collisions between transcription and replication machinery as the genetic material is copied. In cells that lack Dicer, DNA damage accumulates strikingly (yellow spots in the cells above), leading to DNA rearrangements that are associated with aging and disease.

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Cold Spring Harbor Laboratory/ Jie Ren and Stephen Hearn

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