Cytoskeleton Controls Hippo Pathway and Cell Proliferation in the Fly Embryo (IMAGE)

Instituto Gulbenkian de Ciencia

Cytoskeleton Controls Hippo Pathway and Cell Proliferation in the Fly Embryo

Caption

In normal tissue, with an intact cytoskeleton (in purple), the Hippo complex blocks the Yorkie protein (Yki, in green) from activating proliferation genes in the nucleus (image on the left). When the cytoskeleton is deregulated, Yorkie is free to enter the nucleus and activate proliferation of the cell (image on the right).

Credit

Florence Janody, IGC

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Please credit FLorence Janody, IGC

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