Biointegrated microlaser used for real-time tracking of individual cell contractility of nonphagocytic adult cardiomyocytes. (IMAGE)

Light Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS

Biointegrated microlaser used for real-time tracking of individual cell contractility of nonphagocytic adult cardiomyocytes.

Caption

a, Single-cell monitoring with an intracellular microlaser. b, 3D arrangement of myofibrils around microbeads in neonatal cardiomyocytes (CMs). Cell nucleus (magenta) and microlaser (green). c, WGM spectrum of a microlaser and its shifting. d, Microlaser attached to the atrium of a zebrafish heart. e, Refractive index change between the resting phase, diastole, and peak contraction, systole, for 12 individual cells. f, Extracellular microlaser on top of an adult CM. Scale bar 30 μm. g, Trace of a spontaneously beating neonatal CM during administration of 500 nM nifedipine. Adapted with permission from Schubert M. et al. Monitoring contractility in cardiac tissue with cellular resolution using biointegrated microlasers. Nature Photonics 14, 452-458, (2020).

Credit

by Nikita Toropov, Gema Cabello, Mariana P. Serrano, Rithvik R. Gutha, Matías Rafti, Frank Vollmer

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