Mouse at Decision Point in T-Maze (IMAGE)
Caption
To receive a reward, a mouse in the T-maze had to remember whether it had turned left or right on the previous trial, and turn in the opposite direction. Mice genetically engineered to lack a specific segment of genetic material on Chromosome 22, a known cause of schizophrenia -- like patients with the disorder -- faltered at such working memory tasks, because of poor functional connections between the brain’s executive and memory hubs.
Credit
Torfi Sigurdsson, PhD, Department of Psychiatry, Columbia University
Usage Restrictions
None
License
Licensed content