Bone tissue formation rates and expression of sirtuin in bone tissue of old mice (IMAGE)

Kumamoto University

Bone tissue formation rates and expression of sirtuin in bone tissue of old mice

Caption

(a) Mouse vertebral tissue: The amount of bone (dyed in black) is reduced in Sirt7 knockout (KO) mice compared to wild type (WT) mice. (b) The bone formation rate and number of osteoblasts decreased in Sirt7 KO mice compared to WT mice. (c) Expression of nucleic sirtuin in bone tissue of old (2-yr old) mice is less than in young (12-wk old) mice. (Student's t-test: *p?

Adapted from Fig. 2 of Fukuda, M., Yoshizawa, T., Karim, M. F., Sobuz, S. U., Korogi, W., Kobayasi, D., ... Yamagata, K. (2018). SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix. Nature Communications, 9(1). doi:10.1038/s41467-018-05187-4.

Credit

Dr. Tatsuya Yoshizawa

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