3D Cultures of Control Cells and Cells that Over-Express VRK1 (IMAGE)
Caption
When mammary epithelial cells are grown in a 3D culture matrix, they proliferate and form hollow colonies that mimic the organization of an epithelial tissue. 3D cultures of control cells (left) and cells that over-express VRK1 (right) behave very differently in this context. Although all cells organize into colonies and form cell:cell junction markers (red, cadherin), VRK1 over-expression leads to much more vigorous cell proliferation and the formation of larger colonies. These results may have relevance to the colonization of tissues during cancer metastases. (images taken from Mon, MacKinnon and Traktman, PLoS One)
Credit
Created by Paula Traktman from images appearing in Figure 5C of the September 4, 2018 article by Mon, MacKinnon and Traktman, as allowed by the Creative Commons License (https://creativecommons.org/licenses/by/4.0/)
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