Theory of Gene Therapy by AAV-PQBP1 (IMAGE)

_Tokyo Medical and Dental University

Theory of Gene Therapy by AAV-PQBP1

Caption

In Alzheimer's disease state, the nuclear scaffold protein SRRM2 and the synapse-gene regulator PQBP1 are decreased. By increasing PQBP1 in neurons, expression of synapse genes are recovered and cognitive defects are rescued in Alzheimer's patients.

Credit

Department of Neuropathology, TMDU

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